Clinical Research
Reliable Evidence from Small Populations: Rare-Disease Design Options
Evaluate precision, Bayesian methods, repeated measures, adaptive designs and external controls when populations are limited.
6/20/2026
8 min
Blog
Biostatistics Knowledge Center
Educational articles on statistical methods, SPSS usage, and academic research.
Category:All(11 articles)
Clinical Research
Transparency in Trial Registration: Completing PRS Records Accurately
Plan PRS access, protocol fields, outcome definitions, quality control and record updates using official ClinicalTrials.gov guidance.
6/20/2026
9 min
Clinical Research
Consent Participants Can Understand: From Information to Voluntary Choice
Treat consent as an ongoing process, with clear key information, risks, voluntariness, data use and comprehension checks.
6/20/2026
9 min
Clinical Research Methods
Seven Scientific and Participant-Focused Checks for Ethics Applications
Check scientific validity, risk–benefit balance, consent, privacy and protocol consistency before ethics review.
6/20/2026
9 min
Clinical Research Methods
What Should Be Tested Before the Main Study? Pilot and Feasibility Design
A pilot study should test feasibility rather than prove effectiveness. Plan progression criteria, sample size and transparent reporting.
6/20/2026
8 min
Clinical Research Methods
Defining the Study Population: Designing Defensible Eligibility Criteria
Define eligibility criteria that protect safety and measurement quality without unnecessarily restricting generalisability.
6/20/2026
8 min